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The story of Diablo Immortal is set between the events of Diablo II: Lord of Destruction and Diablo III.
Though the Worldstone lies shattered, Diablo's minions hope to harness the great power remaining in the fragments to revive the Lord of Terror. Mankind is left to deal with the actions of the late Archangel Tyrael as the Worldstone's fragments corrupt the land and restore ancient evils.